Anti-determinism on the march!

Nice piece today from SciCurious, guest blogging over at Scientific American. The post is an analysis of a recent article in Nature claiming that by knocking out serotonin in two different ways (both neurotransmitter production and receptors), they abolished sexual preference. The mice apparently mounted either sex with equal frequency.

SciCurious does a beautiful job dissecting the assumptions in the Nature article, analyzing the data, presenting alternative hypotheses, and looking at the history of the research. For example, the authors might have merely lowered the threshold of sexual activity–an extension of “all girls get prettier at closing time”. Or perhaps the researchers influenced the perception of other cues, for example olfactory cues. “So does this paper prove that there are drastic increases in sexual behavior associated with low serotonin?,” SciCurious writes. “Absolutely. Does it show that low levels of serotonin change sexual PREFERENCE? Well, that’s difficult to say.”

Also, Ed Yong looked at the article from a different but equally skeptical point of view. He points out how difficult it is to translate these kinds of behavioral findings from mice to humans. Further, he writes, “serotonin isn’t all about sex.” When I was a teaching assistant for the Neural Systems and Behavior course at Cornell back in the late 1980s, we used to drill in to the students’ heads the idea that neurotransmitters do not have behaviors. They act in many regions of the brain and influence all sorts of behaviors in ways that are very far from straightforward.

Yong worries (rightly) that anti-gay groups will use findings like this to argue for a simple biological basis for homosexuality, perhaps even proposing serotonin therapy as part of their effort to “cure” it. And SciCurious links to news stories soon appeared suggesting that the researchers had “turned mice gay.”

Such stories illustrate a fundamental fallacy that is one of the gravest dangers of popularizing science. For the sake of argument, let’s say the researchers did in fact eliminate sexual preference. In what sense is “no sexual preference” the same as “gay”? Ans: only in a world so normative that strict, unwavering heterosexuality is the only behavior considered normal. Of course, there are lots of people like that–I read about them all the time. But it is blinkered, naive, and deeply chauvinistic.

Biological and especially genetic explanations of behavior are a double-edged sword. The gay community has oscillated in its support for research to find “gay genes” and other traces of the biological basis of homosexuality. If homosexuality is innate, the reasoning goes, then it is cruel and pointless to try to “cure” gays, in the same way it was cruel to “cure” left-handed people.

But “gay” is a cultural construct. There were no “gays” in Ancient Rome or in 19th century Paris, and there are no gays in the Foré of Papua New Guinea. Here and now, in our culture, we need the term in order to protect human rights that are trampled on by people unreflectively absorbing an outdated cultural taboo on homosexual activity. But in the long run, the ideal should be to get rid of the concept–for us all, in short, to be “gay-blind.”

Good skeptical science writing helps that cause, because it exposes fallacies in the ways we think about science. I’m fine with describing a physiological mechanisms for a behavior, but we need to be careful not to equate mechanism with cause. I’m wary of science writing that talks about the “roots” or the “basis” of complex behavior or disease. It implies a hierarchy that blinds us to many biological mechanisms that work in the other direction. In biology, cause and effect go both directions: behavior changes gene activity as much as gene activity changes behavior. Studies purporting to examine the biological “basis” of behavior rely on cross-species analogies and make unsupportable assumptions about motivation.

In short, a “gay” mouse is a ludicrous concept.



One thought on “Anti-determinism on the march!

  1. Miriam Meisler

    This is reminiscent of the idea that mice that do not swim are depressed. Except that, the non-swimming behavior is modified by anti-depressants, which provides a bit of support for the proposal. But basically, all that can be said about the mice is that they do not swim!


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