Golden opportunity

The fabled Karolinska Institutet (KI). To anyone involved with science in the last century or so, that name springs to the mind’s eye plated with the gold of the Nobel Prize. It conjures images of elegant, wealthy Stockholm, a supermodel of a city: cold to the touch, remote, yet gifted with such stunning beauty, elegance, and wealth that it almost seems unfair, hoarded. Is has the glamor and pomp of royalty, the self-confidence (and cost of living) of New York, yet the cozy social democracy that provides reliable, clean public transportation and schools.

The KI is Stockholm’s crown jewel. Every December, Nobel week transforms almost the entire city into an opulent, charming celebration of science. Historians of science know that the curtain before the prize archives moves slowly forward, revealing the nominations and evaluations of individual laureates fifty years after the prize is awarded. The Chemistry and Physics prize archives are maintained at and administered by the Royal Swedish Academy of Sciences. The Physiology or Medicine archives and prize, however, are administered by and housed at the Nobel Forum, a separate entity on the Karolinska campus. Alfred Nobel constructed an administrative architecture designed to maintain the integrity of his prizes, but the result is Byzantine.

Like the Rockefeller University or the PhD program at Cold Spring Harbor Laboratory, the Karolinska is all science. Almost. They do have a small staff of trained, credentialed historians, who work at the Hagströmer Medico-Historical Library, a medium-sized yet rich collection—larger than Johns Hopkins now, yet much smaller than London’s Wellcome Library)—yet rich collection that focuses on works from the sixteenth through the early nineteenth centuries. Located in a nineteenth century building that was, until recently, a courthouse. The facilities are solid with stone, warmed with wood, and softened by thick rugs.

In May, I had the great fortune to both work in the Nobel Forum archive and to be a guest at the Hagströmer Library. Both were thanks to the effort, persistence, and generosity of Eva Åhren a historian of science and medicine and now the head of the Unit for Medical History and Heritage, which includes the library and also houses a number of scholars in medical history,

The old courtroom at the Hagströmer Library

I first gave the Hagströmer Lecture, a public talk, sponsored by the Friends of the Hagströmer Library, to showcase the value of historical studies of science and demonstrate their relationship to both current science and current events. My lecture, based on my last book, was titled “From medical genetics to genomic medicine.” The main argument is that a medical-eugenic thread runs through Progressive-era eugenics all the way through the birth of medical genetics and the emergence of modern personalized genomic medicine. Thus, the “old, bad eugenics” was less hostile to medicine than scholars have thought—and contemporary medical genetics and genomics have a stronger connection to human population improvement than most of us are comfortable acknowledging. I’ve never seen much intellectual value in making people comfortable.

The lecture took place in what is certainly the most beautiful venue in which I have ever given a talk. It was in the former main courtroom, built on a circular plan, now lined with old books, and lit by a vast picture window that admitted the long Swedish evening throughout the lecture and the following reception.

Judging from the audience and the questions, we got the attention of the Karolinska scientists and some of the intellectual public of Stockholm. After the lecture, we had a luxuriously long question-and-answer period, in which scientists and laypeople alike peppered me with thoughtful questions on everything from the history of European eugenics to CRISPR and the possibility of designer babies. Near the end, Eva and I had a fun one-on-one conversation—a sort of scholarly stand-up routine—about the value and the need for historical studies of science. My argument, as regular readers will know, is that the more dominant science becomes in our culture, the more we need historians to help interpret it. The sciences and the humanities are not—or should not be—in competition. It’s more like human evolution: the better your fine motor skills become, the more valuable it is to have a well-developed prefrontal cortex to aid in planning, strategizing, choosing future options.

Dumanski and me
Ms Dumanski and me, at the podium where they announce the prize. You see? She’s actually very nice!

Having sung, I then had my scholar’s supper: Eva was pivotal in arranging for me to work in the Nobel Forum archives. The entire Physiology or Medicine prize, from sending out the nomination forms to organizing and hosting the meetings of the Nobel Committee, to arranging the banquet is done by three full-time staff. There is no trained archivist, even part-time. The administrator Ann-Marie Dumanski is gatekeeper to the archive and the Nobel Forum. By necessity, one of her principal jobs is to keep out the kooks and riff-raff. Not even my Johns Hopkins and Library of Congress affiliations satisfied her. For me to gain access, we had to persuade her that I was not a loony.


The fierce Ms Dumanski was in a good mood. Indeed, she was warm, welcoming, even chatty. Before handing over the documents I had requested, she regaled us with stories from her years there. The Nobel Prize is not the richest prize in science, but, thanks in large measure to Marie Curie, who won it twice (in 1903 and 1911) it is the most famous and the most prestigious. Some people will do almost anything to get one. They forge nominations. They show up at the front door with their inventions, saying, “I can haz Nobel Prize?” One man mailed them a generic silver trophy, on which he had had engraved:

Nobel Peace Prize

Nature             Science

Awarded to [his name]

The cover letter simply asked that they return the cup to his address, registered mail. That way, he could say, truthfully, that he had received a Nobel prize from the Karolinska Institute! Ms Dumanski said, “That cup will never leave this building!” I began to understand why she needs to be so protective.

Nobel table
Where the Knights of the Nobel (in Physiology or Medicine) congregate

The documents themselves were rich and fascinating. I was looking at the prize for the double helix, to James Watson, Francis Crick, and Maurice Wilkins in 1962. I received every nomination they received (which spanned 1960, 1961, and 1962), as well as some of the evaluations conducted by members of the Nobel committee. You will have to wait for the book for all the details, but the story behind this prize is a good deal more complicated than the histories thus far have told. Maurice Wilkins has a much more interesting role than has been acknowledged, as does Laurence Bragg, the director of the Cavendish Institute, where Watson and Crick (but not Wilkins) worked. This in turn has implications for the social history of DNA, such as Watson’s treatment of Wilkins and Rosalind Franklin in his best-selling book, The Double Helix. Looking at the nominations, one would have expected Watson and Crick to win the prize in Chemistry, not Physiology or Medicine. Nearly all their nominations were in Chemistry—and most did not include Wilkins. But Wilkins had a strong partisan on the Nobel committee, and Bragg and Arne Tiselius (the head of the committee) played a good deal of politics. It is not a coincidence that the Chemistry prize went to two other Cavendish scientists who worked with X-ray crystallography: Max Perutz and John Kendrew. It was a red-letter day for X-ray work, for the Cavendish, and for Bragg.In all, it was an exhilarating trip.

Linnaeus’s house

I haven’t even mentioned the jaunt up to Uppsala before Stockholm, in which I stayed next to Linnaeus’s garden, gave another talk, on DNA, to the history of science colloquium, and saw some of the sights of this charming old university town. These events were organized by another good friend and colleague, Maria Björkman. Maria also did me the indispensable favor of arranging for a graduate student, Felicia Edvardsson, to assist me by translating the Swedish evaluations.
I’ll admit, there was a bit of glamor to the trip. At the Hagströmer, I felt a slightly embarrassing surge of pride as I came onstage via the small back door through which the judge once entered the courtroom from his chambers. At the Nobel Forum, Ms Dumanski allowed me to sit at the seven-meter-diameter table, carved from a single piece of wood, where the Nobel committee deliberates the prizes, and let me stand at the podium where the prize is announced every October. We took a ferry that entered Stockholm harbor—for centuries, the primary way one arrived in Stockholm—with its grandly imposing buildings on full display. These moments are folded now into my life’s narrative, among the colorful stories with which one can bore one’s grandchildren.

Uppsala cathedral makes you believe in *something.*

Most important and valuable, though, were the opportunities to be a real historian: tracking down and poring over difficult-to-obtain documents; discussing both history and the value of history with scientists and the public; and spending time with generous and intelligent colleagues who are also friends.

This was not “collegiality,” the canned concept, often paired with “interdisciplinarity,” that is rife in university mission plans and which largely stands for not pissing anyone off. My experience in Sweden, however, was collegiality without quotation marks. It was the real deal: the genuine mutual affection, the shared joy of working with ideas, books, manuscripts, and past actors, the dedication to humanistic values that is eroding so quickly in today’s neoliberal university.

One can still find pockets of true collegiality. When we do find it, we need to enjoy every second.

A Whig History of CRISPR

“Shitstorm” would be one term of art for the reaction in the genome community to a commentary in Cell by Eric Lander, published on January 14. It presents as a definitive account of the discovery of CRISPR, the “gene editing” technique invented in 2013 and which blasted onto the science pages this year. CRISPR is likely to go down as the most important biotechnological invention since Kary Mullis invented the polymerase chain reaction (PCR).

But I prefer another phrase to describe Lander’s account: “whig history.” The term comes from the Europeanist Herbert Butterfield. In a classic 1931 essay, Butterfield wrote that Whig history was “the tendency in many historians to write [English history] on the side of Protestants and Whigs, to praise revolutions provided they have been successful, to emphasize certain principles of progress in the past and to produce a story which is the ratification if not the glorification of the present.”

The term—now often lower-cased to distance itself from the particularities of British politics—has become historical shorthand for one way to use history as a political tool. It rationalizes the status quo, wins the allegiance of the establishment, justifies the dominance of those in power. One immediate tip-off to a Whiggish historical account is the use of melodramatic terms such as “heroes” in the title.

Lander’s piece is called “The heroes of CRISPR.”

In April 2014, the Broad Institute at Harvard and MIT—of which Lander is the director— was awarded the first patent for CRISPR technology. The team of Jennifer Doudna (UC Berkeley) and Emmanuelle Charpentier (Umeå University, Sweden) filed their own application seven months earlier, but Zhang obtained fast-track approval. Much remains at stake over CRISPR: fat scientific prizes, almost certainly including a Nobel, as well as further patents. Who claims them will be decided in part by what version of history becomes accepted as “the truth.”

When Michael Eisen, the UC Berkeley/Howard Hughes Medical Institute biologist and astute commentator on genomics read Lander’s article, he went ballistic. In a tweet-blast of righteous indignation, Eisen howled that Lander’s piece minimizes Doudna’s contributions to CRISPR and thus (I’m paraphrasing here) serves as a propaganda organ on behalf of the Broad’s claim to the patent rights. “The whole thing is about trying to establish Zhang paper as pinnacle of CRISPR work,” tweeted Eisen. He continued, “it’s a deliberate effort to undermine Doudna and Charpentier patent claims and prizeworthiness.” It is, he believes, “science propaganda at its most repellent.” “Eric Lander and @broadinstitute should be ashamed of themselves.”

Others have joined in to express their dismay. At the least, many in the community think, some sort of conflict-of-interest statement should have accompanied Lander’s article. A long thread at PubPeer is devoted to the kerfluffle.

Is Eisen right? I’ll leave analysis of the technical arguments over the relative merits of each group’s contributions to the biologists. What I can do is look at the paper itself. Good writers know how rhetoric can be used to persuade. Does Lander use writing techniques to advance a self-interested version of history?

On first read, Lander’s piece seems eminently fair, even generous. It “aims to fill in [the] backstory” of CRISPR, Lander writes; “the history of ideas and the stories of pioneers—and draw lessons about the remarkable ecosystem underlying scientific discovery.” He traces CRISPR’s origins all the way back to Francisco Mojica, a doctoral student at the University of Alicante, in Spain, in 1989. Mojica discovered a new class of repeating sequence that was present in diverse organisms, suggesting widespread taxonomic importance. These, of course, were the first CRISPR sites—clustered regularly-interspaced short palindromic repeats. By 2000, Mojica had found CRISPR loci in 20 different organisms.

By turning his lens on such unsung heroes, laboring away at universities well beyond the anointed labs of Harvard, MIT, UCSF, Johns Hopkins, and the like, Lander creates the impression of inclusiveness, of the sharing of credit among all the “heroes” of CRISPR.

But when he reaches Doudna and Charpentier’s chapter in the story, the generosity becomes curiously muted. Though Lander maintains his warm, avuncular tone, Doudna and Charpentier enter the story as brave soldiers, working shoulder to shoulder with others on the long journey to practical application of CRISPR. Some subtle techniques create a very definite impression.

For example, Lander narrates Charpentier’s story alongside that of the Lithuanian scientist Virginijus Siksnys. But Siksnys receives top billing. His name appears in the first line of two sections of the paper:

Screen Shot 2016-01-18 at 10.38.28 AM

Screen Shot 2016-01-18 at 10.40.57 AM

Charpentier’s name, on the other hand, appears at the bottom of a paragraph devoted to a component of the CRISPR-cas9 system called tracrRNA.

Screen Shot 2016-01-18 at 10.38.53 AM

Jennifer Doudna is graciously given the epithet “world-renowned,” which may distract our attention from the fact that her first mention is buried in the middle of a paragraph, in the second half of a long sentence, the direct object rather than the subject of the sentence:

Screen Shot 2016-01-18 at 10.45.59 AM

Doudna and Charpentier go neck and neck with Siksnys through the next sections, but Doudna and Charpentier’s contributions are repeatedly diminished. “Sisnysys submitted his paper,” begins one paragraph. At the end of the paragraph Doudna and Charpentier’s paper receives mention. “Both groups clearly recognized the potential for biotechnology,” Lander writes.

Now, enter Feng Zhang and George Church of the Broad Institute. They receive the longest treatment of any actor in the story—a solid page out of nine pages of text. Then Doudna submits a key paper “with assistance from Church.” This and three other “short [ie., minor] papers,” Lander makes sure to note, “were accepted soon after Zhang and Church’s papers were published in early January, 2013.

Lander concludes his saga with words of benevolent wisdom, extolling the “ecology” of science that produces profound discoveries. History provides optimistic lessons about the idealistic world of pure science, carried out purely for the sake of furthering knowledge. One can almost see Lander dabbing away tears of joy as he writes,

The human stories behind scientific advances can teach us a lot about the miraculous ecosystem that drives biomedical progress—about the roles of serendipity and planning, of pure curiosity and practical application, of hypothesis-free and hypothesis-driven science, of individuals and teams, and of fresh perspectives and deep expertise.

I think Eisen has a point, therefore, in reading the paper as a crafty effort to establish Zhang and Church as the scientists who brought the relay race to the finish line—and to portray their principal competitors for patents and prizes, Doudna and Charpentier, as merely two in a long string of runners.

I’m glad to see other scientists, such as Mojica, receive credit in a major CRISPR narrative. Too often the early players and the scientists at lesser-known universities become lost to history altogether. But we should also recognize how Lander uses those actors to create a crowd in which to bury Doudna and Charpentier. It would have been possible to mention Mojica, Gilles Vergnaud, and others while still giving Doudna and Charpentier their due.

Update 1/19: Both Doudna and Church have said the article contains factual errorsI’ll leave it to the experts to debate the technical details of the science. My argument—stimulated and shaped by Eisen’s tweets—is about the tone and style of the piece. Lander is a public-relations master. He’s a compelling speaker and a sophisticated writer. He’s a giant in the field: he has been a leader in the genome community since early days of the human genome project. He knows exactly what he’s doing.

A Nobel can be split at most three ways, and there are four principal actors. How will the prize be partitioned? Doudna, Charpentier, and Zhang? Zhang, Church, and Doudna? Zhang, Church, and Mojica? I have witnessed the steady PR campaigns of scientists who went on to win Nobels. The Prize is supposed to be wholly merit-based, but, we being humans, reputation matters.

Update: One should also note the gender dynamics of the story. However conscious or unconscious it may be, efforts such as this underscore the often-subtle ways in which “history by the winners” still tends to end up being “history by the men.” Only way that stops is by saying it out loud. Tip o’ the pin to Anne Fausto-Sterling and Alondra Nelson for nudging me on this.

At its best, science is a model of human interaction: cooperative, open, focused on evidence and reason, unbiased by prejudice of ethnicity, gender, sexuality, or disability. But science is no longer done in monasteries. Competition, pride, ego, greed, and politics play all too great a role in determining who gets credit, who wins the prizes, and who gets into the textbooks. As Butterfield recognized, controlling the history is both a perk of coming out on top and, while the battle still rages, a way to cement your team’s role in the crystallizing master narrative.

When a scientific history promises an account of “heroes,” when it is filled with sentimental language “miraculous ecosystem” of “pure curiosity and practical application,” and when that history is written by an individual who has much to gain by the acceptance of his own account, the piece should come with a conflict-of-interest statement—or at least a road-sign reading, “Danger! Whig history ahead.”

PS: See also Dominic Berry’s take on the Lander article, also drawing on the history of science but framing it in terms of intellectual property, here:

Top 10 Things I Learned From Reviewing Richard Dawkins


10) Links between genetic determinism and white supremacy remain strong.

9) The staunchest Dawkins followers got nothin’.

8) Wasps are brainless but extremely aggressive.

7) Opinions on Dawkins split down party lines as neatly as a Congressional vote.

6) Saying, “So, chill” is defensive.

5) When they like you, it’s good writing. When they don’t, it’s “rhetoric.”

4) Fundamentalist atheists HATE being called that. So do it early and often.

3) Incredibly, even an atheist with postgraduate work in ecology and evolution can still be a church-kissing, climate-change-denying reactionary one step to the left of Mike Huckabee.

2) Lay back and let your friends and your enemies duke it out.

1) It is important to log off Twitter with the same number of fucks you logged in with.

“Fascist Park” Recreates Thrills of Tyranny’s Golden Age

Imagine going “on safari” across Europe in 1939. Out of a nearby bunker steps none other than Adolf Hitler. He goose-steps in your direction, glowering. His little mustache twitches. Now you must choose: Siegheil! Or run!

In the latest of a new breed of extreme entertainment such as “Tough Mudder,” the biotech company Tyro-Scene has announced that it plans to recreate the twentieth century’s most vile tyrants and let them compete for resources in a naturalistic setting, while paying customers experience an afternoon of terror, repression, and the threat of genocide. Riffing on the iconic dinosaur-cloning movie series, they are calling it “Fascist Park.”

Inspired by current research into the recreation of extinct species such as the Woolly Mammoth, a company spokesman says Tyro-Scene will create scenarios that will enable customers to truly live the worst horrors of the twentieth century, including Nazism, Stalinism, apartheid, and Maoist communism. No one under 18 is permitted, and the experience is not advised for adults with heart conditions or psychological “triggers.”

idi aminFor those up to the challenge, the park promises to get your pulse racing. At any moment, Benito Mussolini, Josef Stalin, Idi Amin, Pol Pot, or even Hitler himself may pop out from behind a tree and attempt to oppress or even exterminate you.

Fascist Park will be located on nearly 10,000 desolate acres in southeastern Utah. Efforts are underway to terraform the landscape into regions resembling various tyrannical eco-systems, including central Europe, North Korea, Uganda, Libya, and Siberia. Customers will ride through the region in armored light patrol vehicles equipped with an add-on landmine protection kit and driven by a former Navy SEAL. Further protection will include issuing all customers an AK-47 rifle and requiring them to watch a fifteen-minute safety video before setting out.

The courageous will have opportunities to leave the vehicle and get “up close and personal” with some of history’s most vile human beings. Guests may be interrogated, waterboarded, or shot at. And because they may drive over land mines, pass through mists of chemical or biological weapons, or give chase, they are urged to wear loose, washable clothing and sturdy shoes.

Reanimating the twentieth century’s most fearsome tyrants may seem like mindless entertainment, but it has both scientific and historical value, the company insists.

“By recreating these dictators in a controlled but naturalistic environment, we can study the biological basis of an array of important human traits, from systematic violence to megalomania to a taste for large, dark sunglasses,” the spokesman said. “Understanding how these genes are shaped by the environment is a crucial step toward preventing genocide going forward.”

Indeed, the park will also be available to research teams who wish to study the dictators in their natural habitat. The Canadian anthropologist Woot Derbyshire, often referred to as “the Jane Goodall of messianic assholes,” plans to be first in line. “So far, I’ve had to rely on computer simulations for my work,” he said. “There’s still so much we don’t know about these sons of bitches, from their mating rituals to their grooming habits.”

Behind the scenes, Fascist Park will be an industrial research park. More than one hundred scientists will labor to maintain stocks of fresh dictators; in the wild, they inevitably impinge on one another’s plans for world domination. This leads to thrilling battles, coups, and sabotage—but it also requires regular replacements.

The park plans to open in November, 2018, with a gala opening featuring a simulated Kristallnacht. Tyro-Scene is already thinking about expanding the franchise. Action figures and plush toys are in the works, as well as customized genealogical DNA kits that will allow customers to find out which dictator they are related to. Also planned is a movie tentatively starring Ellen DeGenerate and George Cloney.

Usmanov: ‘I don’t need no stinking medal’

It’s pledge week again on National Public Radio. Imagine if Bill Gates had called in and told them, “What’s your fundraising goal for this drive? I’ll meet your target right now if you’ll call off the drive”– and NPR said, “Thanks but no thanks—we’ll see what we can get on the phones.”

Alisher Usmanov (from Wikipedia)

It turns out that’s what happened with Watson’s Nobel medal. Christie’s whispered word about the auction in several countries before the sale. Alisher Usmanov, the richest man in Russia, contacted Watson before the auction and made an offer for a financial contribution to the Lab, on the condition that Watson call off the auction, according to the latest report by Anemona Hartocollis in the New York Times (she’s had the Watson auction beat). But Watson turned down Usmanov’s offer. Hartocollis reports that Watson wanted to see how much he could get for the medal.

So Usmanov let Watson hold the auction and then bid on the medal, determined to win—but to not take home his thank-you coffee mug. As one astute Genotopia commenter observed, things have reached a strange state when a Russian oligarch takes the moral high ground.

This latest twist is vintage Watson. I can well imagine him waving away the rotund Russian and his “boring” (my imagining of Watson’s word) offer of a straight gift. I think the thrill of the gamble caught him. Crick (‘s family) got $2.1M for his. Watson was confident he could beat that. But by how much? At the auction, he watched the bidding intently, grinned broadly when it crossed $4M, and celebrated afterward.

In remarks at Christie’s before the auction, he told the audience to always “go for gold.” Silver was never enough, he said. It turns out that he had something specific in mind: he wanted not the “silver” of Usmanov’s initial offer, but the maximum gold he could get for his gold. The gamble, the risk, the competition, the publicity. The chance to take the stage once again, to rile people up, confuse them, yank the public’s chain. It became about him, not the gift.

Watson enjoys playing the scoundrel and he chose, with classic perversity, to punch a few holes in this clichéd last refuge. The reasons to undertake philanthropy are to be–or at least appear–moral, generous, selfless, humane. As the dust settles on this latest bizarre event in Watson’s long career, he ends up seeming competitive, avaricious, and childish. Of all the reasons he gave for wanting to sell the medal, the most oddly touching was the wish to rehabilitate his image. Alas, he has only reinforced it.



Hail Britannia! (Dorkins Reviews Wade)

Editor’s note:
Regular readers of Genotopia will be familiar with Dick Dorkins, a genomicist, faculty member of Kashkow University, and founding President of the Society for the Prevention of Intelligent design, Theology, Or Other Nonsense (SPITOON). Given the forceful nature of some of Dorkins’s opinions, we hesitated when he offered to review this book. But we acceded to his wishes, because we do indeed love our daughter and would, in fact, hate for something to happen to her. One can find a two-part interview with Dorkins here and here

A Troublesome Inheritance: Genes, Race, and Human History, by Nicholas Wade (New York: Penguin) 2014, 288 pp.

Dorkins profile picIt really is a bloody shame that India just had yet another free and fair election, because Nicholas Wade’s new book is so bally good it makes me want to dig out the old pith helmet and mustache wax and jolly well troop off and colonize her again. Since I can’t conquer India, I itch to conquer Mrs. Dorkins and spread my genes, via more little Dorkinses. Alas, Wendy says she has a headache (again!), so the next best thing is to dab my favorite plume into grandfather Dorkins’s inkpot and, in my best public-school hand, pen this little squib on behalf of Wade’s latest. Perhaps I can prompt the some of you lot to do your Darwinian duty and either have or not have more children, depending on your race.

Let me begin by stating that I haven’t read such a stirring work since the sixth form, when our English Master (jolly good word, “Master.” Woody.), Old Man Donglethwaite, cracked the whip and put us through our paces on Lord Acton’s History of Freedom and Herbert Spencer’s What Social Classes Owe to Each Other. For what Wade manages in this book is to resurrect bally old triumphalist English history and social Darwinism, girding them with modern-day genomics. One sincerely hopes that modern science can provide those gallant traditions with a foundation strong enough to last.

Wade, a journalist whose previous books include Before the Dawn: Recovering the Lost History of Our Ancestors and The Faith Instinct: How Religion Evolved and Why It Endures, has composed an argument so elegant, so accessible, so unassailable that it might have been written by Spencer himself—had Spencer known the genetics that supports his ideas. Wade’s fundamental question is not original but rather classic: Why is the West superior to the East—or, god help us, the global South? The truth of this axiom is undeniable: we have the best of everything. The most money, the most freedom, the best science, the neatest gadgets, the finest music and art (never mind Justin Bieber), the strongest militaries, and the most money. Granted, in sports we sometimes lose, and you have to include North America in Europe even though many of the Americans’ achievements are by ethnic Africans and Asians, so it gets a little messy if you examine it too closely. But those are fine points. In the War of the Continents, it’s Europe all the way—and mostly Great Britain—if you look at it right.

Bleeding-hearts such as the anthropologist Jared Diamond have feebly explained the Rise of the West as accidents of geography and climate. Social “scientists” such as Ashley Montagu and the population geneticist Richard Lewontin (honorary social scientist, because he’s so political) have tried miserably to erase the very question of race, as if denying that the term has meaning could make it go away. Burlap-clad, politically-correct academics have even strapped on their Birkenstocks and paraded around the quads, protesting entire fields of inquiry that bear crucially on this question. Only an ideologue would deny the freedom of science to merely ask the question, for example, why white people are smarter than blacks. But Wade—whose peer-reviewed scientific articles have never been called into question—points out that such arguments are disqualified because those wuzzle-headed liberals have an ideology, something that of course has no place in modern science. No, Wade staunchly insists, true science must be blind to values and morals. It must deal exclusively with facts. Wade selects his facts brilliantly, using the latest and best of Western science to explain why Western science is the latest and best. The answer, he courageously concludes, is that we Westerners have better genes.

He argues irrefutably that behavior is shaped by genes, as demonstrated by an Everest of evidence in animals and in humans. Evolution did not stop when the first African hunter-gatherer stepped from his dugout onto the mighty shores of Europe to begin the painful process of civilization; nor did it cease when some enterprising Mesopotamian plucked a leathery handful of wild wheat seeds and poked them purposefully into the Fertile Crescent; nay, nor did it halt even at the coronation of James II in 1633, as he began his campaign to rein in Parliament in the name of liberty. Natural selection is still with us, ruthlessly but efficiently plucking society’s fittest, sweeping the best alleles across the land like so much seed corn. Though it pains one to say it, really it does, the result is that in the genetic lottery some are winners and others are losers. The winners, self-evidently, are those who have been globally dominant these last seven centuries or so: we Westerners, and most especially—here I lower my eyes, reflecting the humility that is my birthright—the British. And, alright, the Americans, who are, or at least were, mostly British. Okay and the Jews. Who, one notes, Britain and America welcomed with open arms after the war, ensconcing them in our finest universities as much as our quotas would allow.

History is not made by individuals, insists Wade. It is made by peoples. Peoples with the finest qualities. Qualities such as patience, thrift, innovation, openness, nonviolence, and civility. Demonstrating those very qualities himself, Wade acknowledges that there have been minor blips along the way, such as colonialism and the Third Reich. One might add slavery, the Columbian Exchange, and the Crusades. But these are mere trifles compared to the wise stewardship with which we have managed the planet over much of the preceding millennium. The practically invisible hand of the free market has brought untold riches to literally hundreds of people worldwide. It has rendered arable vast trackless wastelands of rainforest, making it possible to raise beef cattle for millions of our beloved Big Macs. For much of this period, our oceans and rivers teemed with plump and tasty fishes; likewise the skies with birds and the plains and tundra with wild game. And today, the climate is becoming ever more interesting and will, within a few short decades, bring the luxury and tranquility of coastal life to millions of people now toiling their lives away inland. All this and of course much more constitute the fruits of these peoples. Our peoples. Your peoples. But not their peoples.

The qualities that have made these developments possible, Wade shows, are probably genetic. At least partly. Wade, a journalist, has for decades covered the genetics beat for a little paper you might have heard of called The New York Times. He has extraordinarily broad secondhand knowledge of the arcane panoply of research coming out of Western laboratories published in English; which is to say, the most important, reliable, cutting-edge, and objective facts in the world. So when he says that the traits that underlie the rise of the West are probably at least partly genetic, you know he has read some papers in reliable major journals that seem to suggest this. In addition, Wade cites a wealth of objective, ideology-free facts by leading thinkers such as Charles Murray (co-author of The Bell Curve), Arthur Jensen—whose bold article of 1969 (pdf) demonstrated that compensatory education must fail, because objective, ideology-free science shows that blacks are simply not as intelligent as whites—and Richard Lynn, a British—note—distinguished psychologist and eugenicist who sits on the board of the objective, ideology-free Pioneer Fund, as well as that of the Pioneer-Funded journal Mankind Quarterly, which soldiers on as an objective, non-ideological stronghold of classical eugenics, social Darwinism, and white supremacy in an academic world that has moved leftward in lockstep, as if manipulated by a socialist puppeteer. Murray’s, Jensen’s, and Lynn’s writings, it must be observed, are controversial, an objective fact that may be partly explained by an occasional propensity toward language that can be taken the wrong way—as racist, social Darwinist, or eugenic. Wade, then, has become a cheerful cheerleader for a network of fearless scholars associated with what some have uncharitably branded “scientific racism,” but which I prefer to call “racial scientism.”

In short, if the West has won—and anyone who says otherwise is asking for a drone strike—it is because we are an intelligent, gentle, open, and creative people, and also because we have, as the Americans would say, a Big Gulp of Whoopass in the cup-holder of our figurative Escalade. Genetics suggests that genes underlie social traits such as intelligence, gentleness, creativity, and whoopass. Western populations must therefore have higher frequencies of the alleles for these traits. And so, little ones, we prevail not because might makes right, but because right makes might. We are on top because this is the natural order of things. As the Yale sociologist William Graham Sumner so aptly put it, “A drunkard in the gutter is just where he ought to be.” One might add that an upper-class Briton running over that drunkard in a mint-condition 1970 Aston Martin is just where he ought to be.

One quibble, to reinforce my objectivity: the book’s only serious problem is the title. This inheritance isn’t troublesome at all. It’s marvelous—for someone with the good taste to be born upper-class, C. of E. (Church of England, sod it), and Oxbridge-bred, like Wade and me, anyway. And yes, you marmots, in fact I was born Oxbridge bred: if five generations of Dorkins Firsts doesn’t breed it into you then epigenetics is a joke. What could be troublesome about my inheritance? I closed the cover of this pioneering work of retrograde science writing with a wink and a plummy little smile, lit my pipe, and reflected on how good it is to be rich, brilliant, tall, and English. On top of the world, dominant in every way that matters, and here not by force but by right, dammit, Mother. Did you hear my fist—beknuckled with a light pelage, masculine but not atavistic—pound my oaken desk? The cats lit’rally jumped off the divan.


Is Eugenics Ever Okay?

A flurry of eugenics-related news over the last couple of weeks demonstrates that we have to stop considering eugenics a historical period and think about it more as an ever-present theme. In my book I called it “the eugenic impulse”—not to invoke some sort of misty, mystical force but rather simply to point to something that seems deeply part of our nature. Which is not to say part of our DNA. My research convinced me of two things:

1) Mixed with the chauvinism, intolerance, and paternalistic governmentality of Progressive-era eugenics was an impulse to prevent disease and disability using state-of-the-art knowledge of heredity. 

2) Mixed with present-day impulses to prevent disease and disability using state-of-the-art knowledge of heredity is a great deal of hype motivated more by the desire for profits than by humanitarian concerns.

In short, I could not escape the conclusion that some aspects of contemporary genetic medicine—both good and bad—are indistinguishable from some aspects of Progressive-era eugenics—both good and bad.

The Science of Human Perfection is my attempt to wrestle with the question, “Is eugenics ever okay?” Because I have refused to come down on the side of the dogmatic anti-eugenicists, some pro-eugenics types, eager for recruits, have marshaled my words for their cause. At the same time, some antis have accused me of supporting the enemy. If I make the argument that modern medical genetics comes from the same rootstock as Progressive-era eugenics, they fear that anti-abortion fanatics will use my work as ammunition to repeal Roe v. Wade.

To those of you on both extremes, here’s my answer: No, eugenics is not okay. It scares the crap out of me, to be honest. But it’s happening anyway. No one—and certainly not a historian—is going to stop us from using genetic technology in the attempt to perfect the human race. The most intelligent response is to point out (and so hopefully avoid) the greatest risks.


For years, historians of eugenics have maintained that the term eugenics is no longer helpful. It is too loaded, they say; invariably, it invokes the Nazi past. Whatever programs in controlled breeding or self-directed evolution may be going on, it’s alarmist and a distraction, they say, to call them “eugenics.” For years, this was a reasonable and level-headed response, but it is no longer viable. Not because it’s less loaded, but because today’s historical actors are using it.

A growing number commentators from within the scientific community are arguing for a revisitation of eugenics:

“Seeing the bright side of being handicapped is like praising the virtues of extreme poverty. To be sure, there are many individuals who rise out of its inherently degrading states. But we perhaps most realistically should see it as the major origin of asocial behavior that has among its bad consequences the breeding of criminal violence.” (James Watson, “Genes and Politics,” 1997)

“We are once again practicing a sort of eugenics” (Matt Ridley, “The New Eugenics,” 2000)

In 2001, the conservative theorist Richard Lynn published Eugenics: A Reassessment, which argues just what you think it does. In 2002, researcher DJ Galton (no relation to the founder of eugenics) considered the new genetics, test-tube babies, and genetic screening and called a spade a spade: Eugenics: The Future of Human Life in the 21st Century.

“Eugenics failed because it was not scientific enough…The role of eugenics in our time is in maximizing [hereditary] information and its availability to those who need it and minimizing the temptation to use the State as the means of enforcing eugenic ideals.” (Elof Carlson, “The Eugenic World of Charles Benedict Davenport,” 2008)

“A new interest in rational discourse about eugenics…should be our goal.” (Maynard Olson, “Davenport’s Dream,” 2008)

“Soon it will be a sin of parents to have a child that carries the heavy burden of genetic disease. We are entering a world where we have to consider the quality of our children.” (Bob Edwards [creator of first test-tube baby])

“Eugenics, once discredited as part of the first wave of social authoritarian progressives that trampled free will for women, handicapped people and minorities, is attempting a 21st century comeback.” (Hank Campbell, “Genetic Literacy Project on Neo-Eugenics,” 2012)

“To a great extent we already live in the second age of eugenics.” (Razib Khan, “Eugenics, the 100 year cycle”, 2012)

The most recent is Jon Entine, who runs the Center for Genetic Literacy and writes regularly for the conservative money magazine Forbes. “Instead of being driven by a desire to ‘improve’ the species,” he writes, the “new eugenics is driven by our personal desire to be as healthy, intelligent and fit as possible—and for the opportunity of our children to be so as well.” (Jon Entine, “DNA Screening is Part of the New Eugenics—and That’s Okay,” 2013)

No, we are not trying to improve the species—just our children, and our children’s children, and our children’s children’s children,…

Talk of a new eugenics, then, is no longer idle hand-wringing. When our actors themselves are using the term, historians and philosophers need to take notice and help make sense of it.


The fact that Entine writes for Forbes, Ridley for the National Review, and Lynn for Mankind Quarterly suggests a linkage between the new eugenics and conservative ideologies. Eugenics has long had such associations. Some of the neo-eugenicists (e.g. Lynn) are ideologically linked to the old, discredited eugenic ideologies. But others (e.g., Ridley, Entine) I think are more complicated. Liberals and conservatives, of course, are a diverse lot. When critiquing neo-eugenics, we must bear in mind whether someone is writing from a position of profit-making, preservation of the social status quo, libertarian individualism, or other ideology.

Further, liberals can be eugenicists too. As Diane Paul showed years ago in “Eugenics and the Left,” political liberals were also deeply involved in eugenic schemes during the Progressive era. Most historians of eugenics agree that to a first approximation, everyone in the Progressive era was a conservative. Sterilization legislation was democratically approved, and most sterilizations were carried out in state hospitals, under at least a premise of social benefit. There may well have been a conservative slant to Progressive eugenics, but it was only a slant, and by the 1930s eugenics probably had a liberal slant.

Because of this political ecumenicalism, eugenics today makes for some strange political bedfellows. If some pro-eugenics advocates lean conservative, so do some antis. The Catholic Church—hardly a bastion of liberal fanaticism—opposes eugenics on grounds that it generally entails either abortion or embryo selection. Matt Ridley favors eugenics and is a pro-business conservative. Genetic screening can be seen as a liberal, feminist issue—an issue of women’s choice and empowerment. Or it can be seen as a tool of government social control. Finally, genetic screening and eugenics are not necessarily the same thing. The Center for Genetics and Society supports abortion and genetic screening but seeks to establish a critical biopolitics that can help shape policy to reap the benefits and avoid the risks of reproductive technologies—a position Entine constantly takes them to task over, presumably because they are not simple cheerleaders.

Eugenics, then, does not hew unswervingly toward either pole of the political spectrum. The eugenics question forces us to parse some traditionally liberal and conservative ideas in new ways. Favoring genetic technology is pro-business (conservative). Favoring prenatal genetic diagnosis with abortion is pro-choice (liberal). Fearing the power of genetic manipulation falling into the hands of totalitarian regimes: liberal. Favoring open markets and “consumer choice”: pro-business conservative. Sometimes this consumer-driven eugenics is even called “liberal eugenics.” Perhaps that’s a smokescreen, but maybe not entirely.

Political ideology, then, can’t help us make an easy decision on whether eugenics is ever okay. If the new eugenics has a conservative tilt it’s only a tilt, and there’s plenty of counterweight on the other side. Unfortunately, we’re going to have to make up our own minds.



To do that, we first have to accept that the eugenic train has left the station. Understood as “the self-direction of human evolution” (the slogan from the 1921 eugenics congress and for me still the most inclusive definition I’ve found), eugenics is going to happen. Is happening. Always happens. For now, it’s still mainly for elites who can afford expensive IVF and genetic screening, but the cost of those procedures is dropping rapidly and more people are gaining access to it each year. Many people are in fact currently making eugenic choices, from the wealthy who can afford prenatal genetic diagnosis with selective abortion to the Dor Yeshorim who screen for and discourage marriage between carriers of Tay-Sachs and a range of other genetic diseases. On this much, I agree with folks like Entine. Where we part company is that I’m not nearly so sanguine about it as he seems to be.

Recognizing that we are grasping the reins of human evolution as fast as we can raises two sets of concerns. First, “What if it doesn’t work?” It’s been argued for some time that our technological capacity greatly outstrips both our wisdom and our understanding. It’s often argued that genetic choices have been made since the dawn of marriage, so opposition to techniques such as embryo selection is mere technophobia. But even age-old holistic breeding practices have unpredictable, undesired effects. Sweet-tempered Laborador retrievers tend to get hip dysplasia and eye problems. Great Danes’ hearts fail. Some quarter horses are prone to connective tissue disorders or “tying up” episodes related to their highly bred musculature. The European royal families are prone to hemophilia and polydactyly. Selecting for single genes, rather than traits that involve suites of genes that have evolved together, seems likely to exacerbate such unintended consequences. The emerging science of systems biology holds that genes act—and hence evolve—in networks. Selecting for particular genes rather than complex traits disrupts those networks and is likely to have unpredictable effects.

We in fact have very little idea how the genome works. The genome is like an ecosystem, a brain, or the immune system: an immensely complex, deeply interconnected system. Altering one element or a few elements has effects that are not only unknown but in many cases unpredictable. Evolution, Darwin showed, is an immensely slow process, in which innumerable parts “negotiate” with one another to produce the best-adapted organisms in a given environment at a given time. In taking control over that process, we will be altering the “ecology” of the genome, and it’s bound to have similar effects to our impact on the environment. With great wisdom, it might be handled safely, but experience does not give one much hope for collective human wisdom.

The second concern is, “What if it does work?” What if it does indeed become possible to select traits—health, height, complexion, intelligence—without creating cruel monsters? I have enough faith in technology that I think this may eventually happen. Some unforeseen consequences will doubtless occur, but in time they will become correctable. So what do we do when this becomes possible? We need to keep in mind that this will be a tool of the upper strata of society for a good long time. The rich will do it more than the poor, and Americans and Europeans will do it more than Bangladeshis and Somalians. So it will be a way of inscribing socioeconomic status literally in our DNA. This is in fact a conservative application, because it will tend to reinforce the socioeconomic status quo.

Further, in most developed countries, it’s not government control we need to worry about; it’s corporate control and the tyranny of the marketplace. Advertisers will push certain genotypes. Ad campaigns, current styles, and the rapidly shifting current consensus on what is or is not healthy will shape people’s genetic decisions. And of course, you can’t shed your genome the way you can last year’s fashions. The concern here, then, is that the new eugenics harnesses long-term processes in the service of short-term goals.  This too will have unpredictable effects. History shows without a doubt that societies are rarely wise; we have great trouble seeing several moves ahead, planning for the future, delaying gratification, or sacrificing some of next quarter’s earnings so that we may reap greater health and happiness some time in the future. Even more troubling than failures of technology, then, are failures of morality. And glib reassurances that we are beyond Nazi-style totalitarianism do little to comfort me. The age of self-interested individualism can be just as scary as that of communal self-sacrifice.

Most critical analyses of past eugenic efforts have centered on race, class, and gender. I think that the greatest concern with the new eugenics will likely be the fourth member of the “big three”: disability. Another recent story concerns the stunning development of a method of “silencing” chromosomes. Every nucleated cell in a woman’s body uses this to turn off one of her two X chromosomes; otherwise, women would have a double dose of X chromosome genes, which would lead to lots of problems. The advance is in harnessing this technique so that it can be applied to non-sex chromosomes. Down syndrome results from an extra (third) chromosome 21. The blogs and papers have been awash lately with speculations about “shutting off” the extra chromosome 21 in embryos, to prevent Down syndrome.

The problem is that the severity of Down’s is unpredictable. A family might well be happy to have a high-functioning Down’s baby, but a severely affected child suffers greatly, as does its parents. Who would take that chance? If (when) this technique becomes widely medically available, the frequency of Down syndrome will drop, simultaneously reducing suffering among the victims and families of severe Down’s and joy and love among those close to high-functioning Down’s patients. No humane person would never wish, say, Down syndrome on a family not equipped to handle such a child. But nor would I want to live in a society lacking in people with Down syndrome, or little people, or the blind. It’s not a wish for suffering; we all suffer. But engineering our own evolution will likely have a normalizing effect. Intolerance of abnormality was, indeed, a common refrain among Progressive-era eugenicists and greater power over our genetic future is only likely to increase it. The movie GATTACA got this much right: genetic disease leads to suffering—but so does intolerance.


Is eugenics ever okay? On the individual scale, of choosing not to raise a child with a debilitating disease, I think we have no moral choice but to condone it. A prospective parent talking with a genetic counselor about whether to prevent a deformed or diseased baby from being born is in fact a form of eugenics. But my research made it irrefutable that eugenics has always been simultaneously about individuals and populations. Individual choices lead to population changes—and individual choices are influenced by more than objective genetic knowledge. Although those parents’ choice is for their family rather than the race, they are simultaneously participating in the self-direction of human evolution—it is a choice that any Progressive-era eugenicist would have condoned. And, granting the right to abortion and embryo selection, that is an entirely moral choice.

But what influences that parent’s choice? The biomedical industry hides truly fantastic profits behind the cloak of “health.” Moving responsibly into this inevitable future demands that someone call out the self-interest of the diagnostics and pharmaceutical companies, the instrument-makers and laboratories, the hospitals, the advertisers, and the investors in this new age gold mine. It demands analysis of subtle forms of coercion. It demands a jaundiced eye. Skepticism isn’t Luddism, isn’t anti-choice, isn’t anti-health. It’s following the money.

Much as one might wish to do so, the genie can’t be stuffed back into the bottle. The new eugenics is here. This worries me greatly. But worry, by itself, solves nothing. The concerns it raises are too complex for either dogmatism or complacency. It comes with new, subtle kinds of coercion. Science alone cannot be our guide into this brave genetic world. The closer we come to guiding our own evolution, the more important a humanistic perspective—one that takes the long view of history and the broad view of social context—becomes in helping us make sense of it. The future is here, and, dammit, it’s complicated.

[Update 7/26/13 3:20 pm: Changed description of the Center for Genetics and Society to more accurately reflect their philosophy and agenda. H/t Alex Stern.]

Republican Gene Identified

Call it the Biological October Surprise. Last week, just in time to potentially shape the final days of the presidential campaigns, researchers identified a particular form of a gene that is associated with Republican voting patterns. The gene, dubbed Pol-9, showed up in a meta-analysis of Genome Wide Association Studies correlating DNA sequence with exit poll data from the past four presidential elections and six mid-term elections. The findings were published in the October 31 issue of Political Scientism, a leading journal for the geneticization of pretty much everything.

A team from Kashkow University led by Dr. Jeannie Masculator correlated one form of the gene, Pol-9 BolX, with several well-established traits among Republican voters. These included voting against one’s own economic interests, belief in the right to impose one’s values on others, and advocating the rollback of a wide slate of humanitarian and civil rights issues.

The finding comes two years after the discovery of the “liberal gene,” a form of the DRD4 dopamine receptor also correlated with promiscuity, infidelity, and emotionalism.

The Republican Gene seems to be part of an entirely different metabolic and hormonal pathway, but it too has sexual correlates, although they seem to be contradictory. Preliminary findings suggest that Republicans too are predisposed to infidelity but also in this case to polygamy and lack of empathy. Scientists say these findings are still inconclusive and conclude that conclusions therefore are unwarranted, though they warrant further study.

Political strategists were quick to leap on the news. Democratic leaders in charge of the ground game immediately proposed DNA testing as a method of voter identification. Some insiders, who declined to be named for this article, even hinted they might seek to gerrymander certain voting districts by genome sequence. “Republicans have a herd mentality,” our source said. “They tend to live in similar environments.” If these blocs can be split, he said, Democrats have a chance to disarm the “genetic ruling class” that has been coalescing in recent years.

The search for the genetic basis of voting patterns is becoming increasingly mainstream. Social scientists are increasingly turning to genetics to explain complex behaviors, turning away from traditional explanations such as history and economics. “The beauty of the genetic worldview,” according to an editorial in the same issue of Political Scientism, “is that the more we break down the boundaries between genetics and everything else, the more genetic everything else seems.”

Release Mitt Romney’s Genome!

Sociologists say we live in an age of “biological citizenship,” in which our genetic ties are as important as our political ones, and in which communities bound by disease, disability, or allergy can be more close-knit than geographical neighborhoods. In this political season, then, we cannot afford to be ignorant about the biological status of our presidential candidates.

With this in mind, I issue a call for the Romney campaign to release their candidate’s genome sequence. Four years ago, conservatives sought the release of Barack Obama’s birth certificate. Widely perceived by the left as a scam to distract attention from the issues, the tactic nevertheless reflected the right’s alertness to biology as an important factor in fitness for office. They were fighting the wrong battle–the claim was not even 47% true–but genotopia takes the point about biology and politics. We need to know Mr. Romney’s genetic status if he is to be considered for the highest office in the land, that of Tax-Cutter-in-Chief.

As a Mormon, Mr. Romney’s genealogical relationships will surely be thoroughly documented in the Family History Library in Salt Lake City. They will reveal many relevant facts about his biological status. For example, his inbreeding coefficient must, as stipulated by a little-known paragraph in the Republican platform, must be at least 0.75 (where 1.0 means you married your clone). Circumstantial evidence is not sufficient when the stakes are this high—we need to see the data.

Modern genome sequencing can also disclose many genetic conditions that could render one unfit for office:

  • In 2008, both embarrassment and campaign donations could have been spared had John McCain’s predisposition to dementia been identified.
  • A late-onset form of dementia known as Reagan’s disease has been shown to arise in the third year of the Presidential term, in afflicted individuals.
  • Ford’s ataxia, a loss of muscular control in the limbs and neck, leads to lack of coordination and often results in injury, often serious but always comical. Most often seen in former athletes who become politicians, it is inherited as a predisposition that is then made patent through lifestyle choices.
  • Genome-wide association studies have also shown high probabilization of destitution in the grammaticalness thingy of the brain—a condition known as Bushism—that could be devastating for the Decider.
  • Recently, single nucleotide polymorphisms (SNPs, or “snips”) have also been identified that show strong (well, okay, weak—but some, definitely some) correlation with proposed genes for politophobia (morbid fear of government) and aeronautaphasia, the inability to grasp aerodynamics.
  • Multiple Spousal Cadillac Syndrome—once thought relatively benign—has now been decisively linked to the tragic and devastating psychiatric condition hyperpecuniphilia, an obsessive-compulsive disorder that in late stages can lead to the afflicted sitting amid giant piles of cash, running coins through his fingers and crying out, “Mine, ha ha! All mine!”

The only way these and countless other politicogenetic disasters can be decisively avoided is by getting Mr. Romney to step up to the plate and spit into the cup. Indeed, the Romney campaign should be anxious to prove their candidate’s biological fitness. A quick-and-dirty genome profile can be had for a few hundred dollars, and a gold-plated whole genome analysis for a few thousand. We should demand that Mr. Romney produce his entire sequence for public scrutiny and haplotype analysis. Remember: should he win in November, Paul Ryan would be just a SNP away from the Oval Office.

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