Toward a historioriography of science & social media

I love this stuff. The idea for this panel has generated some high-quality discussion around the histsci community. Just wanted to quickly gather them here for anyone thinking about these issues–hopefully we can keep this going!

Jai Virdi excavated her 2010 article from the HSS newsletter, pecked out with a primitive stone tool on a Nokia 8210, on the use of social media by historians of science. It’s chocked full of the history of this topic and prescient reflection on some key issues. I’m blogging about blogging about blogging now, but seriously, this article is golden.

In response, Mike Thicke, over at the Bubble Chamber, posted this great discussion of Ben Cohen’s “Ayers-Onuf axis” and an alternative model for thinking about the connections among social media, popularization, and the pleasures and dangers of being a public intellectual. The comments on this are almost as good as the post itself.

Naomi Lloyd-Jones blogged about a workshop on social media, hosted by the Institute of Historical Research and Social Media Knowledge Exchange. She came away with some good rules of thumb for successful use of Twitter and blogs–and some reflections on what it all means for historians. 

Finally, just to bring together into one post some more of the secondary literature on this topic…

Here’s Ben Cohen’s HSS Newsletter article from 2008, in which he anticipates not only that there will be a thing called the internet but that a small number of historians of science will have an inexplicable drive to blog in it and about it, as well as a more recent article in Endeavour by Michael Barton, reminiscing about the formation of the Bering land bridge and the halcyon days when men were men and the mammoths frolicked and gamboled upon the verdant tundra.

 

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Hilary Rose on eugenics & genetic medicine

Just saw this clip of an interview with the inveterate science critic Hilary Rose with The Guardian. She expresses beautifully and forcefully the idea I try, however awkwardly, to trace in The Science of Human Perfection and, often more humorously, here on Genotopia. She discusses how eugenics has always had a strand of preventive medicine, and how that strand runs continuously down to today’s genetic medicine. And that doesn’t make modern genetics evil. However, we have to be honest about what it is we’re up to. E.g.:

“Preventive [genetic] medicine is eugenics. Now, I’m not going to say I’m totally against eugenics. I just think we need to say what we’re doing.”

Rose is often a fairly radical critic, but this strikes me as a balanced and fair reading. I am ordering the new book Genes, Cells, and Brains, by Hilary Rose and Steven Rose. I expect to post more on it.

How good it would be to see some momentum gather for an honest, non-polemical critique of genetic biomedicine, one in which the aim was not to strap ourselves to the gears and wheels and levers of the machine* but rather to steer it in a positive direction—one that maximally benefits those it is meant to serve.

 

*paraphrase of a favorite quote from my hometown history

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News of genes for: the latest examples—and further reflections on why we persist in believing in them

There is a basic contradiction in the lay response to genome news. Somehow, the more we learn about how complex and nuanced gene action is, the more we seem drawn to “gene-for” explanations. Collectively, we know that genes do not directly determine or control traits, let alone behaviors. And we know that single genes do not produce complex traits, except (maybe) in a few extreme and rare circumstances. There are no genes for; and yet we keep talking about them—possibly more than ever. Why is that?

Individual cases, drawn from current events, both demonstrate my premise and give us some leverage for prying apart the halves of this paradox.

So let’s roll up our sleeves and get started.

 

I stink, therefore I scam

One of the less appetizing findings of genetics is that if you can’t roll your earwax up into a nice, satisfying ball, your gym buddies in all likelihood choose lockers disconcertingly far from yours. The gene ABCC11 codes for a protein that is involved in the consistency of earwax—and that is apparently quite nutritious to the bacteria that produce body odor. There is, in short, a “key gene” that is “basically the single determinant of whether you produce underarm odor or not,” said Ian Day, a co-author of a new study on the behavior genetics of raunchy pits.

All this has been known for some time. A new paper, by Day and colleagues and published in the Journal of Investigative Dermatology, found that many people who lack “the underarm odor gene” nevertheless still wear deodorant.

One the one hand, this shows that genetics often makes very little difference in our lives. I haven’t confirmed the result with my own nose, but accepting for the moment that ABCC11 does in fact code a protein largely responsible for body odor, apparently few people are paying much attention to it. More important than whether we are actually olfactorily offensive, seemingly, is the marketing ploy that presents human beings as innately stinky creatures, who, in order to be socially successful, need to neutralize our natural stench with perfumes and deodorants. We deodorize independently of the presence of body odor.

On the other hand, then, although we are not slaves to our genes, this study suggests that we are slaves to our culture. Cultural norms and values often shape our behavior more than biological “reality.”

Nor surprisingly, the allele frequency for dry earwax/odorless axilla (the anatomical term for armpit; the middle-schoolers in your life will be thrilled to know this term) varies geographically: 98% of people of European ancestry are wet and stinky, while essentially all Koreans and most Asians generally are dry and odorless. In a nice double-header of genetic determinism plus medical Eurocentrism, Medical News Today bowdlerized the story as, “Two percent of people have armpits that never smell.” Of course, other things besides ABCC11 can make you smell bad. Given sufficient antipathy to bathing and/or doing laundry, anyone’s armpits (and everything else) will begin to reek. And it takes a remarkably blinkered perspective these days to report this result as two percent of people—to neglect the roughly 4/7 of the world population that is Asian. The whole thing makes me break out in a cold sweat.

 

Anthill Anarchy

Two more papers made claims that were more than skin-deep. A paper in Nature, not on humans but on fire ants, suggests the existence of a “social chromosome.”  A string of 616 genes was identified that correlates with the type of social system an individual ant will accept: either a single-queen system or a multi-queen system.

If all the workers in a colony carry the B variant only, they will accept a single queen that also carries only the B variant (marked as BB, because the chromosomes come in pairs). But if some workers in the colony carry the b version of the chromosome, the colony will accept multiple queens — but only those queens with a mismatched “Bb” set of chromosomes. From the Roman Empire to Occupy Wall St., with the flip of a switch.

In the 1960s, during the first flowering of human cytogenetics, the finding that a disproportionate number of inmates in a British hospital for the violently insane carried an extra Y chromosome led to the idea of the “criminal chromosome.” So-called XYY males were branded as potential criminals. These unfortunates, it was speculated, were predisposed to violent crime as a result of having an extra dose of maleness, with its attendant propensities toward aggression and lack of empathy. Several serial killers were labeled as XYY (incorrectly, in most cases) and the “my genes made me do it” defense was attempted in court, though never successfully. The XYY controversy made headlines through the late 1960s and early 1970s, particularly when the science-activism group Science for the People got hold of a Harvard study intended to interrogate this and other claims about the effect of extra sex chromosomes on behavior. The controversy died when the research arm of the Harvard study was suspended. Thus ended this particularly primitive version of the fantasy of preventing violent crime by identifying it before it starts by aborting affected fetuses (bg essay). More sophisticated versions would involve large complexes of genes and subtler therapies; medication, say, and counseling, perhaps lifelong.[1]

The implications of the ant study also lie in the area of behavior control, though the present work limits its conclusions to entomology. “Our discovery could help in developing novel pest-control strategies,” said paper co-author Yannick Wurm (I know, I know) of the University of London. For example, a pesticide could artificially deactivate the genes in the social chromosome and induce social anarchy within the colony.” What could possibly go wrong?

 

Gene for humanity

Another new study identified microRNAs–short strings of nucleic acid that regulate gene expression–that are found in human brains and (so far) only in human brains. The blog Why Evolution is True delivers a sober account of the finding: “We have a human-specific molecule, miR-941, that regulates gene expression in our brains, and some of the genes it might have regulated have dropped out of the pathway.”

This modest but interesting finding has been overblown in the media to a “gene for humanity,” says whyevolutionistrue. The term “holy grail” really should be used only in conjunction with killer bunnies but the phrase’s mytho-comic connotations are apt here, I think. How thrilling (and frightening) to think there might be a single gene that holds the key to separating us from the apes! Could a single wayward x-ray to the groin lead to a Cro Magnon blessed arrival, fruit of the loins of a middle-class mom from Dubuque? Could we, by means of genetic engineering and maternal surrogacy, resurrect an extinct humanoid species such as, say, a Neandertal?

 

Search for the root causes of the search for root causes

As always, there are two distinct but connected forces at play in these stories. Gene-for hype occurs on at least two levels. First is the scientific fascination with seeking the hereditary component of anything. The laudable emphasis today on multi-gene complexes and gene-environment interaction has done little to dampen our enthusiasm for seeking the genetic “roots” or “basis” of natural behaviors. The reasons for this are complex, but at least part of the explanation is inherent in the science. Quite simply, environmental influences are hard to analyze using existing scientific methods. So the cutting edge of behavioral research brackets the environment and asks questions that are answerable (and of course fundable). This de facto determinism is built into the style of scientific practice: what counts as interesting is shaped by what is convenient to study.

Second, as scientific results filter outward from the lab to the media outlets and blogs to the public eyeball, the natural and necessary distillation of complex, nuanced findings into plain, sixth-grade-level language easily becomes perverted. How many hits would you get by writing, “Genes regulated by human-specific molecule may have dropped out of cascade pathway thousands of generations ago”? Perhaps the more relevant human-specific trait here is the desire for simple explanations and sensational stories about root causes and “the key” to whatever.

It is tempting to write that this impulse for ultimate causation explains everything about genetic determinism. But that would create more problems than it solves.


[1] Court Brown, W. M. “Sex Chromosomes and the Law.” The Lancet 280, no. 7254 (1962 1962): 508-09; Maclean, N., J. M. Mitchell, D. G. Harnden, Jane Williams, Patricia A. Jacobs, Karin A. Buckton, A. G. Baikie, et al. “A Survey of Sex-Chromosome Abnormalities among 4514 Mental Defectives.” The Lancet 279, no. 7224 (1962 1962): 293-96; Jacobs, Patricia A., M. Brunton, M. M. Melville, R. P. Brittain, and W. F. McClemont. “Aggressive Behavior, Mental Subnormality and the XYY Male.” Nature 208 (1965 1965): 1351-52. doi:10.1038/2081351a0.

Walzer, S., and P. S. Gerald. “Social Class and Frequency of XYY and XXY.” Science 190, no. 4220 (1975 1975): 1228-9; Steinfels, M. O., and C. Levine. “The XYY Controversy: Researching Violence and Genetics.” Hastings Cent Rep 10, no. 4 (1980 1980): Suppl-1-32.

 

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Putting the person into personalized medicine (redux)

Giving a bump to this essay from 2011 for my students in “Individuality in medicine from antiquity to the genome age.” Also took the opportunity to edit it lightly and fix a couple of formatting/coding glitches. (Sorry about the apparent broken image at the top–it doesn’t show up in the editor, so I can’t figure out how to fix it. Any broken sentences, however, are my own fault.)

http://genotopia.scienceblog.com/29/putting-the-person-in-personalized-medicine/

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Risks of a genetic approach to crime prevention

I have a piece in the Hartford Courant‘s special set of editorials on the Sandy Hook tragedy. The headline-writer missed the point–I am not asking whether genetics could help in understanding and preventing such violence. Of course it can yield at least a partial explanation. My concern is the risk of any prevention program grounded in that genetic understanding. That way leads us toward pre-emptive medication of a class of “future criminals”–a frightening prospect indeed.

Adam Lanza

Adam Lanza [photo from The Blaze]

Here’s the piece.

The piece was written two weeks ago. Yesterday, Wayne Carver, the Connecticut Medical Examiner who ordered the genetic analysis, called it a “fishing expedition.” He continued, “but that doesn’t mean you don’t look.” Why doesn’t it? Only because you don’t see the risks as being greater than the benefits, however tiny they may be. My argument is that the risks are greater than we realize.

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And in summary…

A quick thank you to the 126,000 or so eyeballs that fell upon these pages in 2012, and especially to fred bortz, misha, kw, and others who commented on my posts. Pushing boundaries and buttons can be a thankless task. So thank you. It really does help to have some encouragement in this.

According to WordPress, I am becoming known across teh Intertubes as a expert on “genotopia, dorkins, and thalassophilia.”

I also briefly fooled an MD (but not a nephrology social worker), ribbed and made friends with a genome exhibitionist, found pink ribbons in disturbing places, invented several new genes, and summoned an old eugenicist from the dead.

 

Hey, it’s a living–oh, wait…

Here’s the whole report:

http://jetpack.me/annual-report/20690792/2012/

 

 

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Criminomics: stopping crime before it starts

Criminomics Bears Fruit: 2037 Murder Rate Lowest Since 1964

 

Dylan looks like any normal six-year-old. He is bright and a little mischievous, has many friends, and is praised by his teachers as a model student. But his normalcy is only skin deep. In his cells lies the DNA of a murderer.

Though Dylan has gene variants that give him a more than 90% chance of premeditated mass murder, he will never commit a crime. Thanks to early intervention by doctors, Dylan’s criminal tendencies were identified before birth. Rather than abort the fetus, however, Dylan’s parents agreed to an intensive program of medication and counseling that will all but ensure that Dylan will lead a happy, normal, peaceful life.

Dylan is one of the success stories of the Criminal Genome Project, or CGP, the effort to sequence the complete set of genes involved in murder and other antisocial behaviors. The controversial science on which this project is based—criminomics—is winning converts, now that the latest crime figures are in. Last year, the annual murder rates in 8 American cities dropped to double digits for the first time since the middle of the twentieth century. In Washington, DC, only 90 people died by gunshot last year, down from 103 in 2036. Experts attribute the drop to criminopathy, a medical and public-health approach to crime based on criminomics. The criminomic method uses high-speed genome sequencing to to identify criminal tendencies at birth and begin treatment early in life. Clinical trials for criminal-gene therapy, which would eliminate antisocial tendencies permanently, are underway and, though preliminary, are showing promising early results. The first criminopathic patients are just hitting their 20s now—and the peace is deafening.

The CGP is run by Dr. Bart O’Day, a criminomicist at the Baler Agricultural and Behavioral University in the Republic of Texas. O’Day wrote the grant proposal that funded the project after a tragic shooting at an elementary school in Connecticut in 2012 in which 20 children and 6 adults were killed by a lone gunman. Thankfully, such a crime has since become unimaginable, thanks to the efforts of O’Day and his colleagues.

“It was an obvious thing to do,” O’Day said. “In the years just before the CGP, we had sequenced the cancer genome, the influenza genome, the pseudome, the schizome, and the retardome. The criminome was just lying in wait for us. So the science was there. All we needed was the motivation.”

In fact, the motivation had been there for 150 years. In the 1870s, the Italian criminologist Cesare Lombroso defined a “criminal type,” characterized by distinctive facial features and, ironically, the excessive use of tattooing, which he used in one of the first systematic attempts to prevent crime by biological methods.[1] About the same time, the Victorian polymath Francis Galton developed “composite photography,” in which he superimposed images of faces as a means of identifying the “criminal type.” “If criminals are found to have certain special types of features, that certain personal peculiarities distinguish those who commit certain classes of crime,” observed Edmund DuCane, one of the leading criminologists of Victorian England, “the tendency to crime is in those persons born or bred in them, and either they are incurable or the tendency can only be checked by taking them in hand at the earliest periods of life.”[2]

With the creation of the science of genetics after the turn of the last century, vaguenesses such as “inborn tendencies” and “heredity” hardened into “genes.” In 1914, the American psychologist Henry H. Goddard wrote, “The criminal is not born; he is made.” Goddard traced criminality to mental retardation, or “feeble-mindedness,” in the term of the day. By compassionately treating feeble-mindedness, Goddard believed one could prevent crime. The feeble-minded type, Goddard wrote, was “misunderstood and mistreated, driven into criminality for which he is well fitted by nature. It is hereditary feeble-mindedness not hereditary criminality that accounts for the conditions.”[3] Goddard believed he had found a single Mendelian gene for feeble-mindedness. By breeding it out of the population, he thought he could eliminate crime, as well as poverty, prostitution, and much illness. Though the feeblemindedness gene has been discredited, Goddard’s belief that crime is a genetic disease rather than a perverse exercise of free will has transformed our criminal justice system.

The decisive step was in reframing crime in terms of public health rather than justice. In the early1990s, the National Institute of Alcohol, Drug Abuse, and Mental Health (today subsumed under the National Institute of Genomics) undertook a massive Violence Initiative based on similar principles. It pursued a public health approach to urban crime, which, proponents recognized, was based on biology (and therefore, ultimately, genes).[4] Uncontroversial at first, liberal opposition to the effort mounted, ultimately leading to the canceling of a scientific conference on genetic factors in crime in 1992.[5] This first Violence Initiative died a rather brutal and noisy death. Yet work on the biological basis of crime continued apace. In 1995, a Danish twin study identified the first crime gene, and more were identified shortly after the turn of the century.

But it was high-speed genome sequencing, combined with sophisticated methods of correlating complex behaviors with DNA sequence, that finally provided the technological breakthrough to stop crime before it starts. After the 2012 school shooting, it took a full year for O’Day’s team to sequence the criminal genome (today it could be done in an afternoon). But in 2014, they published paper describing 112 gene variants that together account for more than 99% of predisposition to murder. The genes were patented and licensed to pharmaceutical companies, and seven new targeted therapies were quickly added to the standard psychiatric armamentarium of anti-depressants and anti-psychotics. The federal Violence Initiative was reinstated in 2015 as the Institute of Crime Prevention (ICM), a branch of the National Institutes of Mental Health.

The first mandatory screening for criminal tendencies was put in place in Washington, DC, in 2018. Other states quickly followed; today, only West Dakota and North Virginia lack screening laws. Convicted murderers were the first to be screened. The ICM then tied crime screening to the back-to-school vaccination requirements for students in secondary and primary schools. Most states now test babies at birth, with blood from the standard heel-stick. Babies born with greater than 50% chance of committing murder have their standard RFID chips, implanted in every child at birth, encoded with the designation “Precrim.”

Individuals identified as precriminal are placed under the care of a criminopathic physician, assigned a health care worker, and given criminal prophylaxis: a treatment regimen tailored to their genetic and environmental circumstances. In all cases, this involves a combination of medications and counseling designed to maintain equanimity, promote sociality, and minimize the risk of triggers, including certain music and video games. Teachers and the parents of friends can discretely scan the child and take steps to minimize conflict and quickly intervene should violence erupt. Most states now prohibit the guardians of precrims from keeping firearms in their homes. NRA members oppose such bans, pointing out that since precrims can be dosed so as to ensure docility with a wide margin of safety, prohibiting guns in precrim homes is overkill.

Combined, these methods have proven remarkably effective. Murder rates began dropping as soon as the programs were put in place, but as the first neonatal precrims hit their teens, rates began to plummet. The rates of other violent crimes have also begun to fall, though somewhat more slowly: rapes are down in most states, as are armed robberies and even grafitti and illegal dumping. Scientists at the CGP explain these results by hypothesizing that many criminal behaviors share a common genetic mechanism, possibly related to emotional intelligence.

For all its success, the program has its opponents. Eugene Galton, a member of the Galton dynasty of scientific criminologists, recognizes the benefits of the criminopathy program but thinks the social costs are too high. “Liberty is too high a price to pay for safety,” he says. “We’re ceding our free will to an iatrocracy—a government by the doctors.”

Such philosophical musings carry little weight with inner-city residents who now sleep more peacefully, without the constant pops of gunfire that once punctuated the night. Dylan’s mother sees safety as the best kind of freedom: “I prefer a war with drugs to a War on Drugs,” she says. “I love my son; I’d rather put chemical bars around his mind than steel ones around his body.”


[2] Galton, “Composite portraits,” 143.

[4] Extrapolating slightly from Breggin, Reclaiming our children, p. 52.

[5] New York Times, Sept. 5, 1992, front page. See also Allen, Garland E. “Modern Biological Determinism: The Violence Initiative, the Human Genome Project, and the New Eugenics.” In The Practice of Human Genetics, 1-23, 1999.

 

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